Selected Publications

Selected publications in peer-reviewed journals describing the novel bioenergetic cardioprotective drug, Cyclocreatine Phosphate (Nourexal®) and the novel Nourin® molecular biomarkers, as well as the anti-inflammatory drug, Cyclosporin H.

Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-inflammatory Drug that Resuscitates Poorly Functioning Hearts and Protects Against Development of Heart Failure.
1. Salwa A. Elgebaly, Charles Van Buren, Robert Poston, Reem K. Arafa, Nashwa El-Khazragy, Donald Kreutzer, Mostafa A. Rabie, Ahmed F. Mohamed, Lamiaa A. Ahmed,and Nesrine S. El Sayed: Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-inflammatory Drug that Resuscitates Poorly Functioning Hearts and Protects Against Development of Heart Failure. Pharmaceuticals J., 16,453, 2023.
Integrated Bioinformatics Analysis Confirms Nourin miRNAs are Biomarkers of Myocardial Ischemia
2. Salwa A. Elgebaly, W. Frank Peacock, Robert H. Christenson, Donald L. Kreutzer, Ahmed Hassan Ibrahim Faraag, Amir Mahfouz Mokhtar Sarguos, and Nashwa El-Khazragy. Integrated Bioinformatics Analysis Confirms the Diagnostic Value of Nourin-Dependent miR-137 and miR-106b in Unstable Angina Patients. Invited Paper to the Special Issue “New Insights into Cardiovascular Diseases in Basic Research”, Int. J. Mol. Sci. 2023, 24(19).
Review - Cyclocreatine and Nourin
3. Elgebaly SA, Poston R, Todd R, Helmy T, Almaghraby A, Elbayoumi T, Kreutzer DL.: Cyclocreatine Protects Against Ischemic Injury and Enhances Cardiac Recovery During Early Reperfusion. Expert Review of Cardiovascular Therapy, 17:9, 683-697, 2019 (REVIEW).
Cyclocreatine Phosphate and Heart Failure
4. Elgebaly, S.A.; Van Buren, C.; Todd, R.; Poston, R.; Rabie, M.A.; Mohamed, A.F.; Ahmed, L.A.; El Sayed, N.S.: Cyclocreatine Phosphate: A Novel Mechanism for Preventing Development of Heart Failure. Circulation J. Virtual Meeting – 17 Nov. 142:A13311, 2020.
5. Elgebaly, S.A.; Todd, R.; Kreutzer, D.; Christenson, R.; El-Khazragy, N.; Arafa, R.; Rabie, M.; Mohamed, A.; Ahmed, L.; El Sayed, N. Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure. Int J Mol Sci. Apr; 22(7): 3575, 2021.
Nourin-Dependent miR-137 and miR-106b Novel Biomarkers
6. Elgebaly, S.A.; Christenson, R.H.; Kandil, H.; El-Khazragy, N.; Rashed, L.; Yacoub, B.; Sharafieh, R.; Klueh, U.; Kreutzer, D.L.: Nourin-dependent Mirna-137: A Novel Early Diagnostic Biomarker for Unstable Angina Patients. Circulation J. Virtual Meeting – 17 Nov. 142:A13051, 2020.
7. Elgebaly, S.A.; Christenson, R.H.; Kandil, H.; ElKhazragy, N.; Rashed, L.; Yacoub, B.; Sharafieh, R.; Klueh, U.; Kreutzer, D.L. Abstract 13103: Nourin-dependent Mirna-106b: A Novel Early Inflammatory Diagnostic Biomarker for Cardiac Injury. Circulation J.Virtual Meeting – 17 Nov. 142:A13103, 2020.
8. Elgebaly, S.A.; Christenson, R.; Kandil, H.; El-Khazragy, N.; Rashed, L.; Yacoub, B.; Eldeeb, H.; Ali, M.; Sharafieh, R.; Klueh, U.; and Kreutzer DL.: Nourin-Dependent miR-137 and miR-106b: Novel Early Inflammatory Diagnostic Biomarkers for Unstable Angina Patients. “Special Issue: Molecular Biomarkers in Cardiology”, Biomolecules. Mar; 11(3): 368, 2021.
9. Elgebaly, S.A.; Christenson, R.; Kandil, H.; Rizk, H; El-Khazragy, N.; Rashed, L.; and Kreutzer DL.: Nourin-Dependent miR-137 and miR-106b: Novel Biomarkers for Early Diagnosis of Myocardial Ischemia in Coronary Artery Disease Patients. Diagnostics. Apr; 11(4): 703, 2021.
Cyclosporin H and Lethal Influenza Flu Infection
10. Elgebaly SA, Elbayoumi T and Kreutzer DL.: Cyclosporin H: A Novel Anti-inflammatory Therapy for Influenza Flu Patients. Journal of the Egypt. Soc. of Parasito.: Apr;47(1):25-33, 2017.
11. Elgebaly SA, Daniel Perez, Kathleen Sullivan, Craig Whitaker, Stephanie Caspe, Qiao Yi, and Donald L. Kreutzer. Nourexin-4: A Novel Anti-inflammatory Therapy for Influenza Flu. J. of Immunology. Baltimore, Maryland. April 184 (1 Supplement) 52.1, 2010.
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